Archive for the ‘chantix’ Category

Chantix/Champix

Friday, August 6th, 2010

I’ve been writing an article for another website on the best way to quit smoking (the Allen Carr method wins) and started looking up statistics for Chantix/Champix.

A search quickly throws About.com’s page on Chantix, which seems impressive. According to Terry Martin’s article on the subject users achieved a 22% abstinence rate. Terry didn’t mention the dangers of Chantix, which seems irresponsible (a 22% success rate would probably outweigh the dangers of the drugs, but people should at least have the all the information necessary to make an informed decision.)

Being aware of the fraud surrounding nicotine cessation aids (short term success acclaimed, long term failure ignored) I was a little bit suspicious. Was the cessation rate successful after 1 week, three months or one year? It is relatively easy to give up smoking for a short time, much harder to stay off cigarettes in the long term.In addition, a second reading revealed that only 2 out of 5 studies showed a 22% success rate. Surely one should show the figures as a whole?

As far as I can tell, the cessation rates were at one year. What some digging did reveal was that the trials were conducted by the manufacturer, that the candidates were handpicked, and that intensive counseling was provided to the people on the trial. According to WhyQuit, counselling alone can provide cessation rates of above 25%. There’s also a history of clinical trials proving to be more effective than actual usage. As Healthknot.com points out, trials conducted by manufacturers of nicotine gum produced success rates of 23-43%. However, when the same gum was sold over the counter, only a 7% cessation rate was achieved.

I’m also worried about the side-effects. Doctors promoting the product assure us there are inconsequential. However, with side effects including nausea, vomiting, depression, suicidal thoughts and suicide, I’d like to know exactly what percent of people using the drug experience side effects. I am also very worried by the comments in this (pro-chantix) article, where several people claimed that the depression and suicidal thoughts did not go away – even after usage of Chantix had stopped!

Related:

The Electronic Cigarette versus Chantix
Doctor Opposes Electronic Cigarette
Force Suicide Drugs on Mentally Ill Say Big Pharm Funded Scientists

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A Reply to Dr Mintz on the Electronic Cigarette

Saturday, March 13th, 2010

A certain Dr Mintz seems to be changing his mind on the electronic cigarette!

As we recorded at the time, in his original post he wrote:

“…the electronic cigarette is dangerously being promoted as safe alternatives to cigarettes that contain tobacco as well as possible aids to smoking cessation. Make no mistake: these products are not safe, in some ways could be riskier than cigarettes, will not be effective smoking cessation aids, and are scarily unregulated by the FDA and far too available in the US.”

Now he writes he admits that:

“E-cigarettes are likely a healthier alternative to tobacco smoke…Electronic cigarettes are probably less carcinogenic, than tobacco cigarettes.”

He is still attacking the electronic cigarette, however. Here are his arguments, and our replies.

A Rebuttal

1. Regulation

My objection is not that I am opposed to the existence of electronic cigarette. It’s more that e-cigarettes are not regulated.

We strongly agree that electronic cigarettes should be regulated. We’ve actually had to jump through hoops for the Trading Standards to be able to sell them here in the UK (how other companies manage to get away with selling crap I don’t know; I presume these companies are doing so from abroad.) And we believe that one of the biggest dangers to the e-cigarette industry comes from the cheap and poor quality devices being sold all over the net.

Our problem is not with regulation, it’s how the FDA intends to implement it. And that’s by banning the devices until several years of studies and hundreds of millions of dollars have been spent on them – possibly never. As Judge Leon said, it absurd to impose a more onerous system of regulation on devices which are safer than cigarettes.

While these devices are off the market, users will either use smuggled/home made devices, or stop using them and return to cigarettes.

And some of them will die because of it.

2. Nicotine

Dr Mintz writes:

By vaporizing nicotine, and inhaling it, this will lead to very rapid absorption, and high levels of addiction; possibly even higher than real cigarettes themselves.

Actually, every study done so far suggests that the nicotine delivered to users is far lower than that delivered by cigarettes.

i. A New Zealand study found that the electronic cigarette delivered less nicotine than cigarettes, and Dr Murray Laugeson’s main concern is that they do not contain enough nicotine.

ii. The FDA study found that levels of nicotine were lower than those found in cigarettes.

iii. A more recent study found that electronic cigarettes were delivering very low levels of nicotine – as much, claimed the professor, as sucking an electronic cigarette. This has given risen to the discussion that the main success of the electronic cigarette is in acting as a placebo, and that the role of nicotine in cigarette has been overestimated (perhaps deliberately by those with a financial interest in promoting nicotine cessations aids.)

4. NRT Products

Electronic cigarettes might be safer replacement for tobacco cigarettes, but are not designed to get patients off of nicotine. Generally, most of the nicotine replacement products work by giving patients a continuous supply of nicotine, and eventually weaning that level down once the patient has been off tobacco cigarettes for a few weeks.

Surveys, an informal study in South Africa, the success of the e-cigarette forum (with thirty thousand e-cigarette users) suggest that e-cigarette users can either replace cigarettes with e-cigarettes or quit. However, Dr Mitz is right in that there are no long term studies which prove that electronic cigarettes can help you quit. (And if you enjoy electronic cigarettes, why should you?)

But then, nicotine cessation aids don’t help people quit either.

In the UK the MHRA assumes a 5% success rate with nicotine cessation aids over the long term. That’s abysmal, but it’s a lot better than shown in a recent study which demonstrated a 0.8% success rate – substantially worse than the stand alone quit rate. Dr Mitz is promoting a cessation alternative which is, quite frankly, crap.

5.Chantix

Recently there’s been some concern about safety issues regarding Chantix,…  However, these safety concerns have not seemed to have panned out, and more recent studies seem to indicate that Chantix is very safe given certain precautions, specifically worsening of mental conditions.

If electronic cigarettes had caused people to commit suicide they would be banned by now! It is only because of the huge money behind chantix/champix that they are still being sold. Let’s not forget who pays the bills of the FDA and the MHRA!

See Despite 98 suicides and 188 suicide attempts, FDA favours Chantix.

6. Children

I’m also bothered that electronic cigarettes are sold in our shopping malls, and can potentially be purchased by children.

First, I don’t know a respectable retailer that sells to children. On many sites you have to enter your age before you can buy a site.

Then there’s what Adrian Payne told us:

I’m not aware of any evidence that this is, or is even likely to be, the case. In the first place, E-cigarettes are not ‘pocket-money’ devices. Secondly, I don’t think anyone has raised the same concerns about pharmaceutical nicotine inhalators which, in the UK at least, are available over the counter. Similarly I’m not aware of any evidence of adult non-smokers using either E-cigarettes or pharmaceutical nicotine inhalators in any number as a gateway to smoking – if there were I’m sure we would have heard of it by now. Bad news travels fast!

Read more: http://www.ecigarettedirect.co.uk/interviews/adrian-payne-interview.html

One objection I have to the gateway to smoking argument is that if children are going to go out and buy this sort of device, wouldn’t they be the type of children who are going to buy cigarettes anyway?

7. Conflict of interest

We understand that it is quite normal for opinions to be given by people receiving money from companies with a financial interest in the issue. (We certainly have a financial interest in electronic cigarettes!) However, Dr Mitz perhaps ought to declare  his pharma ties. His failure to do so has caused problems in the past, when he defended the pharmaceutical products on a Forbes blog without declaring that he had been paid funds by the companies that manufactured the products (see A Forbes Guest Blogger and His Pharma Ties.)

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Push Suicide Inducing Drug to Mentally Ill Smokers say Big Pharm Scientists

Friday, September 11th, 2009

A press release issued by two scientists recommends that Zyban or Chantix (Champix in the UK) be subscribed to smokers being treated with mental illness.

Shockingly, the scientists behind the study recommend that counsellors take advantage of the position of trust they have built up with patients to push the drugs, stating:

“They [the study results] find if you take advantage of the relationship with the counselor and insert smoking cessation counseling into treatment that you enhance quit rates.”

Side Effects

Numerous side effects have been reported with these drugs. These side effects include a threat to mental health.

The FDA has received 98 reports of suicide and 188 attempts of attempted suicide with Chantix, and 4,762 serious psychiatric events.

Both drugs now carry a health warning that usage may lead to suicidal thoughts.

According to Thomas Moore, a scientist at the Drug Safety and Policy Institute for Safe Medication Practices, doctors and patients should consider recommending alternatives to the drugs

Source: Calgary Herald

Conflict of Interest

What was not mentioned in the press release was a financial conflict of interest discovered by Professor Michael Siegel.

Both the scientists had received funding from big pharm.

One scientist, Dr George had received grant support from Pfizer, Sepracor, Targacept, and Sanofi-aventis, and is a consultant to Pfizer, Prempharm, Glaxo-SmithKline, Eli Lilly, Janssen-Ortho, and Evotec.

Source: Tobacco Analysis Blog

The Broader Picture

We are not recommending that these drugs should be removed.

It estimated that around a third of smokers will die from smoking related diseases, and that 1% of Chantix users will suffer side effects.

Assuming these statistics are correct (and we all know the famous saying) it seems like an obvious choice, and one which smokers should be allowed to make should they wish to quit.

Just like it is an obvious choice to use electronic cigarettes, which scientists such as Dr Joel Nitzkin estimate has less than one percent of the risk of cigarettes. (See an Interview with Dr Joel Nitzin.)

The difference being, unfortunately, that electronic cigarettes do just not have the same money behind them as the nicotine cessation aids marketed by Big Pharm.

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Doctor Opposes Electronic Cigarette

Wednesday, April 8th, 2009
The number one SEO tip should be say something negative about the electronic cigarette or e-juice – it is a guaranteed way of getting both comments and links to your blog from fervent e-cigarette supporters.
No exception is a blog post on the electronic cigarette by Dr Mathew Mintz – currently building up to 20 comments. In the post Dr Mintz ridicules the excellent Health New Zealand website for their defence of the electronic cigarette, stating:

“…the electronic cigarette is dangerously being promoted as safer alternatives to cigarettes that contain tobacco as well as possible aids to smoking cessation. Make no mistake: these products are not safe, in some ways could be riskier than cigarettes, will not be effective smoking cessation aids, and are scarily unregulated by the FDA and far too available in the US.”

Why Dr Mintz is wrong:

- There is already some convincing evidence that the electronic cigarette is safer than the cigarette. Human trials are continuing but there are already some pretty good product assessments, including that of Murray Laugesson, who concluded that they are “very safe relative to cigarettes, and also safe in absolute terms on all measurements we have applied.”
- There is irrefutable evidence that cigarettes are dangerous, with estimates that 1/3 to 1/2 of smokers will die from a smoking related disease. Essentially Dr Mitz is arguing that we should favour a product that we are certain will kill millions over a product that we are pretty certain is safe.
- There is a convincing support for the electronic cigarette from Tobacco Harm Reduction Experts. David Sweanor, for example, stated:

“If there is anyone who believes cigarettes are no more hazardous than e-cigarettes I’d recommend a remedial course in basic sciences.”

China Argument
Dr Mintz also uses a further ridiculous if common argument:

“Currently, most e-cigarettes are made in China and bought on the internet, where it is very difficult for federal agencies to regulate.”

As we have pointed our before, a huge proportion of our goods are made in China, including a large proportion of medicine. To argue that a good should be banned because it is made in China is not only racist but nonsensical. And what has he got with selling over the internet – does he want to close Amazon down?
Recommending the Alternatives that Don’t Work
It is clear that Dr Mintz is interested in stopping smoking via other methods, stating:

There is now very good evidence and current guidelines recommend that EVERY smoker interested in quitting be offered medication. This can be in the form of nicotine replacement such as the patch or gum. Pills have be shown to be even more effective and both bupropion and Chantix are available by prescription.”

However, according to Dr Nitzkin only 5% of those who try to give up smoking using smoking cessation aids quit when success rates are measured over a year.
Dr Mintz, however, wants us to try Chantix. While few side effects have been recorded with e-cigarettes, plenty have been reported with Chantix. Here’s what one user reported feeling after trying the drug:
  • headache
  • sleep problems and insomnia
  • unusual dreams
  • nausea
  • stomach pain
  • indigestion
  • vomiting,
  • constipation
  • gas
  • weakness
  • tired feeling
  • unpleasant taste in mouth
By recommending the current state of affairs continue – promoting ineffective nicotine cessations aids or aids which users stop using because of side effects, while continuing to remove the choice of using safer products such as smokeless tobacco, Doctors like this this are essentially recommending that we continue to let smokers die.
I wonder why?

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